Реакция #47804

Уравнение реакции

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

methylmagnesium chloride

→

titled compound

Выход 38.0%

1-hydroxy-6-methoxy-1-methyl-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

Выход 38.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   ПромывкаThe resulting mixture washed with saturated saline
2. 2
   Экстракцияextracted with ethyl acetate
3. 3
   ДругоеThe organic layer was separated
4. 4
   Сушкаdried over anhydrous MgSO4
5. 5
   Концентрированиеconcentrated under a reduced pressure
6. 6
   ДругоеThe resulting residue was purified by flash chromatography

Методика

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (300 mg, 0.974 mmol) obtained in Example 1 was dissolved in THF and 1.2 equivalents of methylmagnesium chloride were added thereto, followed by stirring for 3 hrs at 0° C. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 126 mg of the titled compound (yield: 38%).

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