Реакция #476113

ord-1e2c57d8435a494fbfd58c668e0566d9

Уравнение реакции

CC(C)c1ccccc1Nc1nc2ccc(C(=O)O)cc2[nH]1
2-(2-Isopropylphenylamino)-3H-benzimidazole-5-carboxylic acid
Nc1ccc2c(OCCN3CCOCC3)n[nH]c2c1
3-(2-morpholin-4-ylethoxy)-1H-indazol-6-ylamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HBTU
→
CC(C)c1ccccc1Nc1nc2ccc(C(=O)Nc3ccc4c(OCCN5CCOCC5)n[nH]c4c3)cc2[nH]1
2-(2 isopropylphenylamino)-3H-benzimidazole-5-carboxylic acid [3-(2-morpholin-4-ylethoxy)-1H-indazol-6-yl]amide

Реактанты

CC(C)c1ccccc1Nc1nc2ccc(C(=O)O)cc2[nH]1
2-(2-Isopropylphenylamino)-3H-benzimidazole-5-carboxylic acid
Nc1ccc2c(OCCN3CCOCC3)n[nH]c2c1
3-(2-morpholin-4-ylethoxy)-1H-indazol-6-ylamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HBTU

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

2-(2-Isopropylphenylamino)-3H-benzimidazole-5-carboxylic acid (0.3 mmol; see Example 66) was coupled with aforementioned 3-(2-morpholin-4-ylethoxy)-1H-indazol-6-ylamine (0.3 mmol) using HBTU as described in general procedure D to afford the desired product, 2-(2 isopropylphenylamino)-3H-benzimidazole-5-carboxylic acid [3-(2-morpholin-4-ylethoxy)-1H-indazol-6-yl]amide. MS: m/z 540 (M+H)+.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08377983B2uspto-grants-2013_02