Реакция #475952

Уравнение реакции

piperidine-4-carbonitrile

tert-butyl 2-oxoethylcarbamate

sodium triacetoxy borohydride

→

oil

Выход 91.0%

tert-butyl 2-(4-cyanopiperidin-1-yl)ethylcarbamate

Выход 91.0%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   ДругоеSolvent was evaporated
2. 2
   workup.ADDITIONethyl acetate was added
3. 3
   Промывкаwashed with water
4. 4
   ДругоеThe solvent was removed in vacuo
5. 5
   Другоеto provide oil
6. 6
   ДругоеThe crude oil was purified by column chromatography (100% ethyl acetate)

Методика

A mixture of piperidine-4-carbonitrile (1.10 g, 10 mmol), tert-butyl 2-oxoethylcarbamate (1.59 g, 10 mmol) and sodium triacetoxy borohydride (2.5 g, 12 mmol) in 25 ml of CH2Cl2 was stirred at room temperature overnight. Solvent was evaporated and ethyl acetate was added and washed with water. The solvent was removed in vacuo to provide oil. The crude oil was purified by column chromatography (100% ethyl acetate) to yield colorless oil (2.3 g, 91%).

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