Реакция #47436

Уравнение реакции

(S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid ethyl ester

lithium hydroxide monohydrate

→

(S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt

Выход 126.3%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Другоеthe solvents evaporated
2. 2
   ПромывкаThe residue was rinsed with diethyl ether which

Методика

To a solution containing (S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid ethyl ester (0.120 g, 0.29 mmol) in tetrahydrofuran (4 mL) was treated with an aqueous solution of lithium hydroxide monohydrate (0.5N, 1.2 mL, 0.6 mmol). The mixture was stirred at 25° C. for 2 h, and the solvents evaporated. The residue was rinsed with diethyl ether which afforded (S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt (0.140 g, 100%) as a yellow solid.

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