Реакция #47419

Уравнение реакции

hydrogen peroxide

2-fluoro-3-methyl-phenylboronic acid

acetic acid

→

2-fluoro-3-methyl-phenol

Выход 98.0%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Другоеto come to room temperature
3. 3
   ДругоеThe mixture was evaporated
4. 4
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
5. 5
   Промывкаwashed with hydrochloric acid (0.5N), water and brine
6. 6
   ДругоеThe organic phase was dried
7. 7
   Фильтрацияfiltered
8. 8
   Другоеevaporated which

Методика

To a solution of 2-fluoro-3-methyl-phenylboronic acid (25.0 g, 0.162 mol) in tetrahydrofuran (220 mL) was added glacial acetic acid (150 mL). The resulting mixture was cooled to 0° C. before hydrogen peroxide (50% aqueous solution, 30 mL) was added. The resulting mixture was allowed to come to room temperature and stirred for 24 h. The mixture was evaporated and the residue was dissolved in ethyl acetate, washed with hydrochloric acid (0.5N), water and brine. The organic phase was dried, filtered and evaporated which afforded 2-fluoro-3-methyl-phenol (20.0 g, 98%) as an oil.

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