Реакция #473780

Уравнение реакции

water

potassium carbonate

8-methanesulphonyloxy-1,4-dioxa-spiro[4.5]decan

3-benzyl-3,4-dihydro-4-oxo-6-hydroxy-7-methoxy-quinazoline

potassium carbonate

8-methanesulphonyloxy-1,4-dioxa-spiro[4.5]decan

→

3-benzyl-3,4-dihydro-4-oxo-6-(1,4-dioxa-spiro[4.5]decan-8-yl-oxy)-7-methoxy-quinazoline

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.ADDITIONeach added three times
2. 2
   workup.STIRRINGin each case the mixture is stirred for several hours at 80° C
3. 3
   ТемператураThe reaction mixture is cooled
4. 4
   Фильтрацияfiltered
5. 5
   Промывкаwashed with water
6. 6
   Другоеdried

Методика

16.0 g potassium carbonate and 20.0 g 8-methanesulphonyloxy-1,4-dioxa-spiro[4.5]decan are added at 50° C. to 20.0 g 3-benzyl-3,4-dihydro-4-oxo-6-hydroxy-7-methoxy-quinazoline in 150 ml N,N-dimethylformamide and the mixture is vigorously stirred for 18 hours at 80° C. To complete the reaction potassium carbonate and 8-methanesulphonyloxy-1,4-dioxa-spiro[4.5]decan are each added three times and in each case the mixture is stirred for several hours at 80° C. The reaction mixture is cooled and slowly combined with a total of 500 ml of water. The precipitate is suction filtered, washed with water and dried.

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