Реакция #472801

Уравнение реакции

tert-butyl (2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate

hydrochloride

→

1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one trihydrochloride

Растворители

isopropyl alcohol

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Температураthe mixture was heated
3. 3
   Температураunder reflux
4. 4
   Фильтрацияthe solid was filtered off

Методика

To a suspension of 0.30 g of tert-butyl (2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate in 1.8 mL of isopropyl alcohol, 0.23 mL of concentrated hydrochloride was added, and the mixture was heated under reflux while stirring for 1 hour 50 minutes. The reaction mixture was cooled to 5° C., and the solid was filtered off to obtain 0.28 g of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one trihydrochloride as a light yellow solid.

Источник