Реакция #472717

Уравнение реакции

sodium hydroxide

trifluoroacetic acid

1-(1,3-dioxolan-2-ylmethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one

→

(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Температураunder cooling with ice
2. 2
   ДругоеThe organic layer was separated
3. 3
   Промывкаwashed with an aqueous sodium chloride solution
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Методика

To 184 mL of 80% trifluoroacetic acid, 4.60 g of 1-(1,3-dioxolan-2-ylmethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one was dissolved, and the resultant solution was stirred at room temperature for 11 hours and at 60° C. for 3.5 hours. The reaction mixture was charged with chloroform and alkalified with a 10% aqueous sodium hydroxide solution under cooling with ice. The organic layer was separated, and washed with an aqueous sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain (7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde as a yellow solid.

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