Реакция #472671

Уравнение реакции

1-(1,3-dioxolan-2-ylmethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one

trifluoroacetic acid

trifluoroacetic acid

→

(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde

Выход 120.2%

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture was stirred at 60 to 70° C. for 1 hour
2. 2
   ТемператураThe reaction mixture was cooled to room temperature
3. 3
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
4. 4
   workup.ADDITIONThe resultant residue was charged with ethyl acetate and water
5. 5
   ДругоеThe organic layer was separated
6. 6
   Экстракцияthe aqueous layer was extracted with ethyl acetate
7. 7
   Сушкаthe resultant solution was dried over anhydrous magnesium sulfate
8. 8
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Методика

To 0.11 g of 1-(1,3-dioxolan-2-ylmethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one, 6.0 mL of an 80% aqueous trifluoroacetic acid solution was added, and the mixture was stirred at 60 to 70° C. for 1 hour. Thereto was added 4.0 mL of an 80% aqueous trifluoroacetic acid solution, and the mixture was stirred at 60 to 70° C. for 1 hour. The reaction mixture was cooled to room temperature, and the solvent was distilled off under reduced pressure. The resultant residue was charged with ethyl acetate and water and adjusted to pH 7.0 with a 1 mol/L aqueous sodium hydroxide solution. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined and the resultant solution was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 0.11 g of (7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde as a light brown foam.

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