Реакция #4724

Уравнение реакции

Hydrogen peroxide

N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураthe reaction mixture is briefly heated to boiling
2. 2
   ФильтрацияThe sulphur which separates is filtered off hot with the aid of active charcoal
3. 3
   Концентрированиеthe filtrate is concentrated by evaporation
4. 4
   Другоеpurified by preparative layer chromatography

Методика

2 ml of 30% Hydrogen peroxide are added to 1.58 g (4 mmol) of N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide in 30 ml of ethanol and the reaction mixture is briefly heated to boiling. The sulphur which separates is filtered off hot with the aid of active charcoal and the filtrate is concentrated by evaporation and purified by preparative layer chromatography.

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