Реакция #47109

Уравнение реакции

1-methoxy-2-propanol

ethyl diazoacetate

→

product 473

Выход 64.9%

(2-Methoxy-1-methylethoxy)acetic acid ethyl ester

Выход 64.9%

Растворители

heptane

dichloromethane

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered through Celite
2. 2
   Другоеthe filtrate is evaporated
3. 3
   workup.DISTILLATIONdistilled at 133° C.

Методика

To a solution of 1-methoxy-2-propanol (900 mg, 10.0 mmol) in dichloromethane (20 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (0.95 mL, 9.0 mmol). The reaction mixture is stirred at rt for 30 min. The reaction mixture is diluted with heptane, filtered through Celite, and the filtrate is evaporated and the residue is vacuum distilled at 133° C. to give 1.03 g of the product 473. 1H NMR (CDCl3) δ 4.20 (q, 2H), 3.72 (m, 1H), 3.45 (dd, 1H), 3.37 (dd, 1H), 3.35 (s, 3H), 1.27 (t, 3H), 1.19 (d, 3H).

Источник