Реакция #47077

Уравнение реакции

chloroacetonitrile

2-fluorophenol

potassium carbonate

→

product 384

Выход 97.4%

(2-Fluorophenoxy)acetonitrile

Выход 97.4%

Растворители

EtOAc

DMF

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture is cooled to RT
2. 2
   Промывкаwashed with water, brine
3. 3
   Сушкаdried (MgSO4)
4. 4
   Фильтрацияfiltered
5. 5
   ДругоеThe filtrate is evaporated
6. 6
   Другоеthe residue purified by chromatography on silica gel
7. 7
   Промывкаelution with dichloromethane

Методика

To a solution of 2-fluorophenol (560 mg, 5.0 mmol) in DMF (10 mL) is added potassium carbonate (828 mg, 6.0 mmol) followed by chloroacetonitrile (0.315 mL, 50.0 mmol). The reaction mixture is stirred and heated at 50° C. for 14 h. The reaction mixture is cooled to RT, diluted with EtOAc, and washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue purified by chromatography on silica gel; elution with dichloromethane gives 736 mg of the product 384.

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