Реакция #47067

Уравнение реакции

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2,5-dichlorobenzyl chloride

→

product 238

Выход 49.6%

2-[(2,5-Dichlorobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

Выход 49.6%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Другоеevaporated to dryness
2. 2
   ФильтрацияThe insoluble material is filtered

Методика

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2,5-dichlorobenzyl chloride (327 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 175 mg of the product 238. 1H NMR (DMSO-d6) δ 11.50 (s, 2 H), 8.00 (s, 1 H), 7.70-7.50 (m, 2 H), 7.20-7.00 (m, 6 H), 6.95-6.80 (m, 4 H), 5.81 (s, 2 H), 4.90 (s, 2 H); MS: m/z 413 (M++1).

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