Реакция #47052

Уравнение реакции

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

4-methoxybenzyl chloride

→

product 223

Выход 51.7%

2-[(4-Methoxybenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

Выход 51.7%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Другоеevaporated to dryness
2. 2
   ФильтрацияThe insoluble material is filtered

Методика

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 4-methoxybenzyl chloride (0.213 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 167 mg of the product 223. 1H NMR (DMSO-d6) δ 11.24 (s, 2 H), 7.50 (d, 2 H), 7.20-6.90 (m, 8 H), 6.90-6.65 (m, 4 H), 5.78 (s, 2 H), 4.78 (s, 2 H), 3.78 (s, 3 H); MS: m/z 375 (M++1).

Источник