Реакция #4705

Уравнение реакции

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methylisocyanate

Ether

→

N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Другоеthe precipitation
3. 3
   Фильтрацияfiltered
4. 4
   Промывкаwashed with ether
5. 5
   Другоеrecrystallised from ethanol

Методика

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.40 g (6 mmol) of methylisocyanate are added and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete the precipitation, and the precipitate is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

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