Реакция #470392

Уравнение реакции

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

Выход 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

Выход 47.9%

Растворители

water

Условия реакции

Обработка

1. 1
   ТемператураAfter cooled to room temperature
2. 2
   ЭкстракцияThe mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   ДругоеThe solvent was evaporated
4. 4
   Другоеthe residue was purified by column chromatography

Методика

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

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