Реакция #470391

Уравнение реакции

2-phenyl-1H-benzo[d]imidazole

ethanol

→

desired product

1-(2-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was heated up
2. 2
   Температураto reflux for 24 hours
3. 3
   Фильтрацияthe precipitate was collected by filtration
4. 4
   ДругоеThe product was purified by column chromatography

Методика

Intermediate 1 (1.5 g, 2.1 mmol) and 142-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole (2 g, 6.4 mmol) were mixed with 30 ml of ethanol in a three-neck flask under nitrogen. The mixture was heated up to reflux for 24 hours. After cooled to room temperature, the precipitate was collected by filtration. The product was purified by column chromatography using 1:2 dichloromethane and hexanes as eluent. 0.7 g of desired product was obtained after purification.

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