Реакция #470387

Уравнение реакции

N1-phenylbenzene-1,2-diamine

benzaldehyde

→

desired product

Выход 37.0%

1,2-diphenyl-1H-benzo[d]imidazole

Выход 37.0%

Растворители

methoxylethanol

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was heated up
2. 2
   Температураto reflux for 48 hours
3. 3
   Другоеthe solvent was evaporated
4. 4
   ДругоеThe residue was purified by column chromatography

Методика

N1-phenylbenzene-1,2-diamine (4.15 g, 22 mmol) and benzaldehyde (2.1 g, 20 mmol) were mixed with methoxylethanol (60 ml) in a three-neck flask. The mixture was heated up to reflux for 48 hours. After cooled to room temperature, the solvent was evaporated. The residue was purified by column chromatography using dichloromethane to 5% of ethyl acetate in dichloromethane as eluent. 2 g of desired product was obtained.

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