Реакция #47038

Уравнение реакции

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2-chlorobenzyl chloride

→

product 208

Выход 32.2%

2-[(2-Chlorobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

Выход 32.2%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Другоеevaporated to dryness
2. 2
   ФильтрацияThe insoluble material is filtered

Методика

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-chlorobenzyl chloride (0.198 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 105 mg of the product 208. 1H NMR (DMSO-d6) δ 11.38 (s, 2 H), 7.90-7.70 (m, 1 H), 7.70-7.55 (m, 1 H), 7.55-7.35 (m, 2 H), 7.20-7.00 (m, 6 H), 7.00-6.85 (m, 4 H), 5.81 (s, 2 H), 4.88 (s, 2 H); MS: m/z 379 (M++1).

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