Реакция #470377

Уравнение реакции

cyclen

2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester

→

product

Выход 81.3%

5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-2-(1,4,7,10-tetraazacyclododec-1-yl)pentanoic acid benzyl ester

Выход 81.3%

Растворители

CH3CN

CH3CN

Условия реакции

Обработка

1. 1
   workup.ADDITIONare added dropwise
2. 2
   ФильтрацияThe precipitate is filtered off
3. 3
   Промывкаwashed thoroughly with acetonitrile

Методика

55 g of cyclen base (320 mmol) are dissolved in 550 ml of CH3CN, to which 119.8 g of brominated derivative (2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester, 288 mmol) dissolved in 550 ml of CH3CN are added dropwise. The medium is stirred at ambient temperature overnight. The precipitate is filtered off and washed thoroughly with acetonitrile. 138 g of product are obtained in the form of a white powder (corrected yield 81.3%).

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