Реакция #470364

Уравнение реакции

sodium carbonate

N-methoxymethyl-N-methylpyrrolidinium chloride

N-Methyl-N-Methoxymethylpyrrolidinium Chloride

→

desired product

N-Methoxymethyl-N-Methylpyrrolidinium Carbonate

Растворители

water

Условия реакции

Обработка

1. 1
   ДругоеThe mixture was reacted at room temperature for 0.5 hour
2. 2
   Другоеwhereby the reaction was terminated
3. 3
   КонцентрированиеThe reaction mixture was concentrated
4. 4
   Сушкаdried in vacuum, and 100 ml of ethyl alcohol
5. 5
   workup.ADDITIONwas added to the residue
6. 6
   Другоеto remove insoluble sodium chloride
7. 7
   workup.DISSOLUTIONThe resulting product was dissolved in dichloromethane
8. 8
   Фильтрацияthe solution was filtered with a membrane
9. 9
   Фильтрацияfilter again
10. 10
    Концентрированиеthe filtrate was concentrated in a vacuum
11. 11
    Другоеdried

Методика

A 1.60 g quantity of sodium carbonate (product of Wako Pure Chemical Ind. Ltd.) was dissolved in 18 g of deionized water, and 5.01 g of N-methoxymethyl-N-methylpyrrolidinium chloride was added to the solution. The mixture was reacted at room temperature for 0.5 hour, whereby the reaction was terminated. The reaction mixture was concentrated and dried in vacuum, and 100 ml of ethyl alcohol was added to the residue to remove insoluble sodium chloride. The resulting product was dissolved in dichloromethane, the solution was filtered with a membrane filter again, and the filtrate was concentrated in a vacuum and dried, giving 5.41 g of the desired product.

Источник