Реакция #47029

Уравнение реакции

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2,4-dichlorobenzyl chloride

→

product 199

Выход 81.3%

2-[(2,4-Dichlorobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

Выход 81.3%

Растворители

EtOH

Условия реакции

Обработка

1. 1
   Другоеevaporated to dryness
2. 2
   ФильтрацияThe insoluble material is filtered

Методика

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2,4-dichlorobenzyl chloride (0.218 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 287 mg of the product 199. 1H NMR (DMSO-d6) δ 11.38 (s, 2 H), 7.95-7.75 (m, 2 H), 7.65-7.50 (m, 1 H), 7.20-7.00 (m, 6 H), 7.00-6.80 (m, 4 H), 5.83 (s, 2 H), 4.90 (s, 2 H); MS: m/z 413 (M++1).

Источник