Реакция #4701

Уравнение реакции

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methyl isothiocyanate

Ether

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Другоеthe precipitate formed
3. 3
   Фильтрацияfiltered
4. 4
   Промывкаwashed with ether
5. 5
   Другоеrecrystallised from ethanol

Методика

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.44 g (6 mmol) of methyl isothiocyanate are added, and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete precipitation and the precipitate formed is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

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