Реакция #46885

Уравнение реакции

(3-Fluoro-4-nitro-phenyl)-pyrrolidin-1-yl-methanone

→

(4-Amino-3-fluoro-phenyl)-pyrrolidin-1-yl-methanone

Растворители

MeOH

Условия реакции

Обработка

1. 1
   ДругоеThe solution was evacuated
2. 2
   Промывкаrinsed with argon several times
3. 3
   workup.ADDITION150 mg palladium on charcoal (10%) were added
4. 4
   Другоеagain the mixture was evacuated
5. 5
   Промывкаrinsed with argon several times
6. 6
   ФильтрацияThe reaction mixture was filtered over “Celite”
7. 7
   Промывкаthe filter residue was washed with 30 mL MeOH
8. 8
   КонцентрированиеThe filtrate was concentrated under vacuo

Методика

515.0 mg (2.16 mmol) (3-Fluoro-4-nitro-phenyl)-pyrrolidin-1-yl-methanone were dissolved in 20 mL MeOH. The solution was evacuated and rinsed with argon several times. 150 mg palladium on charcoal (10%) were added and again the mixture was evacuated and rinsed with argon several times. Finally argon was exchanged by hydrogen (balloon filled with hydrogen) and the mixture was stirred for 2 h at room temperature. The reaction mixture was filtered over “Celite” and the filter residue was washed with 30 mL MeOH. The filtrate was concentrated under vacuo to give pure (4-Amino-3-fluoro-phenyl)-pyrrolidin-1-yl-methanone as a colorless oil.

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