Реакция #46787

Уравнение реакции

5-Chloro-pyridin-2-ylamine

pyridine

bromo-acetyl bromide

→

2-Bromo-N-(5-Chloro-pyridin-2-yl)-acetamide

Растворители

toluene

toluene

Условия реакции

Обработка

1. 1
   workup.ADDITIONwere added dropwise under ice cooling
2. 2
   ДругоеAfter 2 h the precipitate was isolated by filtration
3. 3
   Другоеrecrystallized from toluene
4. 4
   Другоеto yield a white solid

Методика

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.

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