Реакция #46725

Уравнение реакции

HCl

N-(2,4-dihydroxy phenyl)-2,2,2-trifluoro-acetamide

K2CO3

1-bromooctane

→

black solid

Выход 82.5%

N-(2-Hydroxy-4-octyloxy-phenyl)-2,2,2-trifluoro-acetamide

Выход 82.5%

Растворители

DMF

Условия реакции

Обработка

1. 1
   Экстракцияextracted with diethylether (30 mL)
2. 2
   СушкаThe organic phase was dried (MgSO4)
3. 3
   Фильтрацияfiltered
4. 4
   Другоеthe eluate evaporated

Методика

To a solution of N-(2,4-dihydroxy phenyl)-2,2,2-trifluoro-acetamide (0.44 g; 2 mmol) in DMF (4 mL) was added K2CO3 and 1-bromooctane (0.37 mL; 2.1 mmol). The slurry was stirred for 2 days at room temperature, poured onto 0.1 M HCl (aq.; 50 mL) and then extracted with diethylether (30 mL). The organic phase was dried (MgSO4), filtered and the eluate evaporated to leave 550 mg of black solid which was purified by chromatography (SiO2; PE80-100° C./EtOAc=4:1) to leave 100 mg (15%) of a pure white solid. Mp. 114-116° C.; MS (GC-MS; Cl): 334 (MH+).

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