Реакция #4664

Уравнение реакции

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-formylamino-4-oxo-1,4-dihydroquinoline-3-carboxylate

potassium carbonate

ethyl iodide

→

solid

Выход 37.7%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-formylethylamino-4-oxo-1,4-dihydroquinoline-3-carboxylate

Выход 37.7%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   workup.WAITthe mixture is kept for 4 hours at room temperature
2. 2
   Другоеthe precipitate obtained
3. 3
   Фильтрацияis filtered off
4. 4
   Промывкаwashed with water
5. 5
   Экстракцияextracted with chloroform
6. 6
   Промывкаthe extract is washed with water
7. 7
   Другоеthe organic layer is dried
8. 8
   Другоеthe solvent is evaporated off
9. 9
   Другоеthe residue is recrystallized from an ethanol/water mixture (1:1)

Методика

A mixture of 1.5 g (0.005 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-1-formylamino-4-oxo-1,4-dihydroquinoline-3-carboxylate and 1.3 g (0.01 mol) of potassium carbonate in 10 ml of dimethylformamide is stirred for 3 hours at room temperature, 2.35 g (0.015 mol) of ethyl iodide are then added and the mixture is kept for 4 hours at room temperature. It is poured into a water/ice mixture, the precipitate obtained is filtered off, washed with water and extracted with chloroform, the extract is washed with water, the organic layer is dried, the solvent is evaporated off and the residue is recrystallized from an ethanol/water mixture (1:1) to give 0.7 g of a solid melting at 192°-194° C.

Источник