Реакция #466220

Уравнение реакции

3-hydroxy-4-iodo-benzoic acid

2-naphthylboronic acid

triethylamine

→

title compound

4-Iodo-3-(naphthalen-2-yloxy)-benzoic Acid Methyl Ester

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   ФильтрацияThe reaction mixture was filtered through celite,
2. 2
   Концентрированиеconcentrated to dryness
3. 3
   Другоеchromatographed (SiO2, 5-40% EtOAc: hexane)

Методика

A mixture of 3-hydroxy-4-iodo-benzoic acid acid methyl ester (0.505 g, 1.82 mmol), cupric acetate (0.330 g, 1.82 mmol), 2-naphthylboronic acid (0.625 g, 3.63 mmol) and powdered 4A molecular sieves (0.3 g) in CH2Cl2 (21 mL) was treated with triethylamine (1.27 mL, 9.08 mmol) and stirred at ambient temperature for 18 hr. The reaction mixture was filtered through celite, concentrated to dryness and chromatographed (SiO2, 5-40% EtOAc: hexane) to give the title compound. FAB mass spectrum (M+1) 405.

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