Реакция #4660

Уравнение реакции

ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate

potassium carbonate

bromofluoroethane

→

solid

Выход 61.7%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-fluoroethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Выход 61.7%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   workup.WAITleft
2. 2
   Температураto cool
3. 3
   workup.WAITleft
4. 4
   Температураto cool
5. 5
   Другоеthe precipitate formed
6. 6
   Фильтрацияis filtered off
7. 7
   Промывкаwashed with water
8. 8
   Другоеrecrystallized from a dimethylformamide/water mixture (1:1)

Методика

A mixture of 3.2 g (0.011 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate and 4 g (2.5×0.011 mol) of potassium carbonate in 20 ml of dimethylformamide is heated for 30 minutes at 60° C. and left to cool, 7 g (5×0.011 mol) of bromofluoroethane are added, the mixture is kept for 7 hours at 80° C., left to cool and poured into a water/ice mixture, and the precipitate formed is filtered off, washed with water and recrystallized from a dimethylformamide/water mixture (1:1) to give 2.35 g of a solid melting at 231°-234° C.

Источник