Реакция #4659

Уравнение реакции

ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate

potassium carbonate

n-propyl bromide

→

solid

Выход 70.1%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-propyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Выход 70.1%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураis heated for 5 hours at 80°-90° C.
2. 2
   workup.WAITleft
3. 3
   Температураto cool
4. 4
   Другоеthe precipitate formed
5. 5
   Фильтрацияis filtered off
6. 6
   Промывкаwashed with water
7. 7
   Другоеrecrystallized from ethanol

Методика

A mixture of 3 g (0.01 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate, 2.8 g (0.02 mol) of potassium carbonate and 6 g (0.04 mol) of n-propyl bromide is heated for 5 hours at 80°-90° C. and left to cool, water is added and the precipitate formed is filtered off, washed with water and recrystallized from ethanol to give 2.4 g of a solid melting at 128°-130° C.

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