Реакция #4654

Уравнение реакции

ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate

potassium carbonate

methyl iodide

→

solid

Выход 76.4%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate

Выход 76.4%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   workup.WAITleft
2. 2
   Температураto cool
3. 3
   Температураthe mixture is heated at 80°-90° C. for 4 hours
4. 4
   workup.WAITleft
5. 5
   Температураto cool
6. 6
   Другоеthe precipitate formed
7. 7
   Фильтрацияis filtered off
8. 8
   Промывкаwashed with water

Методика

A mixture of 1.5 g (0.005 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate and 1.4 g (0.01 mol) of potassium carbonate in 10 ml of dimethylformamide is heated for 30 minutes at 60° C. and left to cool, 2.15 g (3×0.005 mol) of methyl iodide are added, the mixture is heated at 80°-90° C. for 4 hours and left to cool, 25 ml of a water/ice mixture are added and the precipitate formed is filtered off and washed with water. The precipitate is receystallized from ethanol to give 1.2 g of a solid melting at 253°-254° C.

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