Реакция #46458

Уравнение реакции

2-Bromo-4-methyl-6-iodophenol

cinnamyl bromide

Diisopropylethylamine

→

1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene

Выход 101.2%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe DMF was removed under vacuum, and 1M HCl
2. 2
   workup.ADDITIONwas added until the residue
3. 3
   ЭкстракцияThe mixture was extracted with ethyl acetate
4. 4
   Сушкаthe combined organic phase was dried over magnesium sulfate
5. 5
   Фильтрацияfiltered
6. 6
   Концентрированиеconcentrated under reduced pressure

Методика

2-Bromo-4-methyl-6-iodophenol (7.82 gm, 25 mmol) and cinnamyl bromide (4.93 g, 25 mmol) were added to DMF (20 ml). Diisopropylethylamine (5.3 ml, 30.4 mmol) was added and the mixture heated to 60° C. for 15 minutes and then allowed stir for 16 hours at room temperature. The DMF was removed under vacuum, and 1M HCl was added until the residue was acidic. The mixture was extracted with ethyl acetate, and the combined organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene (10.86 g, 100% yield).

Источник