Реакция #46394

Уравнение реакции

5-amino-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]-thiophene-4-carboxylic acid

formamide

water

→

desired compound

Выход 48.6%

3,3-dioxo-1,2,3,8-tetrahydro-3λ6-thia-6,8-diazacyclopenta-[a]naphthalen-9-one

Выход 48.6%

Растворители

N,N-dimethyl-formamide

Условия реакции

Обработка

1. 1
   Другоеreacted in a microwave at 150° C.
2. 2
   ДругоеDuring the reaction
3. 3
   ФильтрацияThe precipitated solid was filtered off with suction
4. 4
   Промывкаwashed successively with water and diethyl ether
5. 5
   Другоеdried in vacuo overnight

Методика

0.87 g (3.83 mmol) of 5-amino-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]-thiophene-4-carboxylic acid was suspended in 2.0 ml of N,N-dimethyl-formamide and, after addition of 0.76 ml (19.14 mmol) of formamide, reacted in a microwave at 150° C. and 60 W for 40 min. During the reaction, the pressure in the microwave rose to 20 bar. The reaction mixture was then added to water. The precipitated solid was filtered off with suction and washed successively with water and diethyl ether and dried in vacuo overnight. 440 mg of the desired compound were obtained.

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