Реакция #463611

Уравнение реакции

2-fluoro-5-nitrobenzonitrile

→

2-fluoro-5-aminobenzonitrile

Выход 85.7%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Температураat reflux 1.5 h
2. 2
   ДругоеPartitioned between ethyl acetate (150 mL) and saturated sodium bicarbonate(150 mL)
3. 3
   ДругоеOrganic phase was separated
4. 4
   Промывкаwashed with water (5×75 mL), brine (75 mL)
5. 5
   Сушкаdried over sodium sulfate (anhy.)
6. 6
   Фильтрацияfiltered
7. 7
   Концентрированиеconcentrated

Методика

To a solution of 2-fluoro-5-nitrobenzonitrile (2.0 g, 12 mmol) in ethyl acetate(50 mL) was added stannous chloride (27.0 g, 120 mmol). The reaction mixture was stirred at reflux 1.5 h, then cooled to room temperature. Partitioned between ethyl acetate (150 mL) and saturated sodium bicarbonate(150 mL). Organic phase was separated and washed with water (5×75 mL), brine (75 mL); dried over sodium sulfate (anhy.); filtered and concentrated to give 2-fluoro-5-aminobenzonitrile (1.4 g) as pure compound.

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