Реакция #46340

Уравнение реакции

4-Methylsulfonylpyridine

hydrogen peroxide

ammonia

sodium hydrogen sulfite

4-methylsulfanyl-pyridine

→

4-methyl-sulfonylpyridine

Растворители

water

acetic acid

Условия реакции

Обработка

1. 1
   ДругоеThe crude oil obtained
2. 2
   Другоеis crystallized with 10 cm3 of diisopropyl ether
3. 3
   Фильтрацияthe crystals are filtered
4. 4
   Другоеdried under reduced pressure (2.7 kPa)

Методика

4-Methylsulfonylpyridine may be prepared by carrying out the procedure as described in Example 20, starting with 14 g of sodium tungstate, 4 cm3 of water, 0.05 cm3 of 100% acetic acid, 3.3 g of 4-methylsulfanyl-pyridine, 6.5 cm3 of 30% hydrogen peroxide and then 0.25 cm3 of 32% aqueous ammonia and 1 cm3 of 37.5% aqueous solution of sodium hydrogen sulfite. The crude oil obtained is crystallized with 10 cm3 of diisopropyl ether, the crystals are filtered, drained and dried under reduced pressure (2.7 kPa). 2.6 g of 4-methyl-sulfonylpyridine are obtained in the form of white crystals.

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