Реакция #46180

Уравнение реакции

5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole

sodium cyanide

→

(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile

Выход 78.6%

Растворители

dimethylsulfoxide

Условия реакции

Обработка

1. 1
   workup.ADDITIONThe reaction mixture was poured into ice
2. 2
   Экстракцияextracted with ethyl acetate (300 mL)
3. 3
   СушкаThe organic layer was dried over sodium sulfate
4. 4
   Другоеevaporated to dryness

Методика

A mixture of crude 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole (4.4 g) and sodium cyanide (1.36 g, 27.8 mmol) in dimethylsulfoxide (50 mL) was stirred at room temperature overnight. The reaction mixture was poured into ice and extracted with ethyl acetate (300 mL). The organic layer was dried over sodium sulfate and evaporated to dryness to give crude (2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile (3.3 g) which was used directly in the next step.

Источник