Реакция #46166

Уравнение реакции

sodium chloride

N-bromosuccinimide

2,2′-azobisisobutyronitrile

3-Phenyl-6-(3-phenylpropoxy)indene-1-one

→

title compound

Выход 60.0%

2-bromo-3-phenyl-6-(3-phenylpropoxy)indane-1-one

Выход 60.0%

Растворители

carbon tetrachloride

Условия реакции

Обработка

1. 1
   Экстракцияextracted with dichloromethane
2. 2
   СушкаThe extract was dried over anhydrous magnesium sulfate
3. 3
   Концентрированиеconcentrated
4. 4
   Другоеthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:5)

Методика

3-Phenyl-6-(3-phenylpropoxy)indene-1-one (200 mg, 0.586 mmol) was dissolved in carbon tetrachloride, and N-bromosuccinimide (313 mg, 1.75 mmol) and 2,2′-azobisisobutyronitrile (9.7 mg) were added thereto. Then, the mixture was refluxed for 1 hour under a 375 W tungsten lamp. After the reaction was completed, saturated sodium chloride was added thereto and extracted with dichloromethane. The extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:5) to obtain title compound (147 mg, yield 60%) as a red solid.

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