Реакция #46155

Уравнение реакции

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester

hydroxyamine

hydrochloric acid

pyridine

→

1-hydroxyimino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carboxylate ethyl ester

Выход 9.5%

Условия реакции

Обработка

1. 1
   Промывкаwashed with saturated ammonium chloride
2. 2
   ДругоеThe organic layer obtained
3. 3
   Экстракцияby extracting the reaction mixture with ethyl acetate
4. 4
   Сушкаwas dried over anhydrous magnesium sulfate
5. 5
   Концентрированиеconcentrated
6. 6
   Другоеthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2)

Методика

3-Phenyl-6-(3-phenylpropyloxy)-1-oxo-1H-indene-2-carboxylate ethyl ester (2 g, 4.85 mmol) and hydroxyamine.hydrochloric acid (1.01 g, 14.6 mmol) were dissolved in pyridine (1.57 ml, 19.4 mmol). The reaction mixture was stirred for 1 hour at 70° C., and washed with saturated ammonium chloride. The organic layer obtained by extracting the reaction mixture with ethyl acetate was dried over anhydrous magnesium sulfate, concentrated, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:2) to obtain 1-hydroxyimino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carboxylate ethyl ester (yield 9.5%) as a yellow solid.

Источник