Реакция #46123

Уравнение реакции

7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide

potassium carbonate

cyclopropylmethyl bromide

→

7-chloro-4-cyclopropylmethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураthe mixture is heated
2. 2
   Температураat reflux for 24 hours
3. 3
   ДругоеThe reaction mixture is evaporated under reduced pressure
4. 4
   ФильтрацияThe insoluble material is collected by filtration
5. 5
   Промывкаwashed with water
6. 6
   Другоеdried
7. 7
   Другоеis recrystallised from methanol

Методика

To a solution of 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (1 g) in acetonitrile (40 mL) there is added potassium carbonate (2.5 g) and cyclopropylmethyl bromide (0.7 mL) and the mixture is heated at reflux for 24 hours. The reaction mixture is evaporated under reduced pressure and the residue is taken up in water (40 mL). The insoluble material is collected by filtration, washed with water and dried and is recrystallised from methanol.

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