Реакция #46116

Уравнение реакции

2-Chloro-5-nitrobenzenesulphonamide

cyclopropylamine

→

2-cyclopropylamino-5-nitrobenzenesulphonamide

Растворители

dioxane

Условия реакции

Обработка

1. 1
   workup.ADDITIONabove is introduced into a hermetically closed vessel
2. 2
   workup.ADDITIONcontaining
3. 3
   ДругоеAfter this time period, the solvent and the reagent are removed
4. 4
   Концентрированиеby concentrating under reduced pressure
5. 5
   Фильтрацияis collected by filtration
6. 6
   Промывкаwashed with methanol
7. 7
   Другоеdried

Методика

2-Chloro-5-nitrobenzenesulphonamide (5 g) prepared in the Step above is introduced into a hermetically closed vessel containing a mixture of dioxane (70 mL) and cyclopropylamine (3.5 mL). The hermetically closed vessel is placed in an oven at 100° C. for 24 hours. After this time period, the solvent and the reagent are removed by concentrating under reduced pressure. The residue is taken up in methanol (20 mL) and the insoluble material, which contains the title product, is collected by filtration, washed with methanol and dried.

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