Реакция #46113

Уравнение реакции

4,5-dichloro-2-fluorobenzenesulphonamide

cyclopropylamine

→

title product

4,5-dichloro-2-cyclopropylaminobenzenesulphonamide

Растворители

dioxane

Условия реакции

Обработка

1. 1
   ДругоеThe solvent and the excess of amine are removed by distillation under reduced pressure
2. 2
   workup.DISSOLUTIONthe residue is dissolved in methanol (20 mL)
3. 3
   ТемператураThe methanolic solution is cooled on an ice bath
4. 4
   workup.ADDITIONwater (60 mL) is added

Методика

A solution of 4,5-dichloro-2-fluorobenzenesulphonamide (3 g) in dioxane (30 mL) to which cyclopropylamine (3 mL) has been added is heated at 100-110° C. in a hermetically closed vessel for 24 hours. The solvent and the excess of amine are removed by distillation under reduced pressure and the residue is dissolved in methanol (20 mL). The methanolic solution is cooled on an ice bath, and water (60 mL) is added. The precipitate obtained (the title product) is collected by filtration, washed with water and dried. It is used in the following Step without being otherwise purified.

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