Реакция #46010

Уравнение реакции

EtOAc

4-bromophenol

1-fluoro-4-nitrobenzene

potassium carbonate

→

4-bromophenoxy-1-nitrobenzene

Растворители

DMF

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling to rt
2. 2
   Промывкаwashed with H2O (2×50 mL) and brine (50 mL)
3. 3
   Сушкаdried over sodium sulfate
4. 4
   ДругоеThe solvent was removed in vacuuo

Методика

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-bromophenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into EtOAc (100 mL), washed with H2O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-bromophenoxy-1-nitrobenzene. The crude product was used for further transformation.

Источник