Реакция #459252

Уравнение реакции

Jones reagent

1-chloro-2-hydroxy-3-phenoxypropane

water

→

1-chloro-3-phenoxyacetone

Выход 49.7%

Растворители

acetone

Условия реакции

Обработка

1. 1
   ЭкстракцияThe mixture was extracted three times with diethyl ether
2. 2
   Сушкаthe combined ethereal extracts were dried over sodium sulphate
3. 3
   Концентрированиеconcentrated under reduced pressure
4. 4
   Сушкаdried again over sodium sulphate
5. 5
   Концентрированиеconcentrated further
6. 6
   workup.DISTILLATIONdistilled

Методика

8N Jones reagent (100 ml.) was added dropwise to a stirred solution of 1-chloro-2-hydroxy-3-phenoxypropane (28.3 g.) in acetone (100 ml.) during 1 hour while maintaining the reaction temperature at 20° C. The mixture was then stirred for 4 hours, and then sufficient water was added to dissolve the precipitated chromium salts. The mixture was extracted three times with diethyl ether and the combined ethereal extracts were dried over sodium sulphate, concentrated under reduced pressure, dried again over sodium sulphate, and concentrated further and distilled, to give 1-chloro-3-phenoxyacetone (13.9 g.), b.p. 150°-155° C./20 mm.Hg.

Источник