Реакция #4584

Уравнение реакции

2-(2-propanon-1-yloxy)phenylsulfonamide

ethylene glycol

p-toluenesulfonic acid

toluene

→

2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Температураis heated for 7 hours
2. 2
   Температураto reflux
3. 3
   Другоеwhile simultaneously separating
4. 4
   Другоеthe water of reaction
5. 5
   Промывкаthe organic phase is washed with saturated sodium bicarbonate solution and water
6. 6
   Другоеdried
7. 7
   Концентрированиеconcentrated

Методика

A mixture of 4.58 g of 2-(2-propanon-1-yloxy)phenylsulfonamide, 2 ml of ethylene glycol, 0.02 g of p-toluenesulfonic acid and 30 ml of toluene is heated for 7 hours to reflux while simultaneously separating the water of reaction. The cooled solution is taken up in 80 ml of ethyl acetate and the organic phase is washed with saturated sodium bicarbonate solution and water, dried and concentrated, affording 5 g of 2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide in the form of a yellow viscous oil which can be further used without purification.

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