Реакция #4582

Уравнение реакции

phosgene

2-(1-methoxycarbonylethoxy)-benzenesulfonamide

n-butylisocyanate

phosgene

→

2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate

Выход 125.5%

Растворители

xylene

Условия реакции

Обработка

1. 1
   Температураis refluxed for 30 minutes
2. 2
   Температураthe solution is then cooled
3. 3
   Концентрированиеconcentrated in vacuo

Методика

A mixture of 12.9 g of 2-(1-methoxycarbonylethoxy)-benzenesulfonamide, 4.9 g of n-butylisocyanate and 0.1 g of diazabicyclooctane and 130 ml of xylene is refluxed for 30 minutes. Then 10 g of phosgene are passed into the solution at the same temperature over 90 minutes. Excess phosgene is expelled with nitrogen and the solution is then cooled and concentrated in vacuo, affording 17.7 g of 2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate in the form of a brownish oil which can be further used without purification.

Источник