Реакция #45673

Уравнение реакции

N-bromosuccinimide

4-cyano-6-[1-(ethoxy)ethenyl]-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide

→

6-Bromoacetyl-4-cyano-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide

Растворители

tetrahydrofuran water

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was evaporated away under reduced pressure
2. 2
   workup.DISSOLUTIONthe resulting residue was dissolved in ethyl acetate
3. 3
   Промывкаthe solution was washed with water

Методика

Next, at room temperature, N-bromosuccinimide (2.10 g, 11.8 mmol) was added to a tetrahydrofuran/water (178 ml/11 ml) mixed solution of the obtained 4-cyano-6-[1-(ethoxy)ethenyl]-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide (3.56 g, 11.2 mmol), and stirred for 20 minutes. The solvent was evaporated away under reduced pressure, and the resulting residue was dissolved in ethyl acetate, and the solution was washed with water.

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