Реакция #45642

Уравнение реакции

N-(4-Bromo-2-cyano-5-fluoro-6-hydroxy-3-methylphenyl)-2,2-dimethyl-3-[(phenylmethyl)oxy]propionamide

hydrogen

→

compound

Выход 50.3%

N-(4-Bromo-2-cyano-5-fluoro-6-hydroxy-3-methylphenyl)-3-hydroxy-2,2-dimethyl-1-propanamide

Выход 50.3%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   workup.ADDITIONcarbon-held palladium catalyst (5% wet, 580 mg) was added
2. 2
   ДругоеAfter the reaction
3. 3
   Другоеthe insoluble matter was separated by filtration through Celite
4. 4
   Концентрированиеthe filtrate was concentrated under reduced pressure
5. 5
   ДругоеThe resulting residue was recrystallized
6. 6
   Другоеpurified with n-hexane/ethyl acetate

Методика

N-(4-Bromo-2-cyano-5-fluoro-6-hydroxy-3-methylphenyl)-2,2-dimethyl-3-[(phenylmethyl)oxy]propionamide (I-105) (5.82 g, 13.37 mmol) was dissolved in ethyl acetate (120 ml), carbon-held palladium catalyst (5% wet, 580 mg) was added, followed by vigorously stirring at room temperature under atmospheric pressure of hydrogen for 18 hours. After the reaction, the insoluble matter was separated by filtration through Celite, the filtrate was concentrated under reduced pressure. The resulting residue was recrystallized and purified with n-hexane/ethyl acetate to obtain the entitled compound (2.32 g, 50%) as a white solid.

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