Реакция #455980

Уравнение реакции

2-fluoro-4-hydroxybenzoic acid

acetic acid

sulfuric acid

→

4-acetoxy-2-fluorobenzoic acid

Растворители

water

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONmixed
2. 2
   ТемператураAfter heat generation
3. 3
   Фильтрацияa precipitated crystal was recovered by filtration
4. 4
   ДругоеThe crystal was dried in vacuum

Методика

4.3 Grams of 2-fluoro-4-hydroxybenzoic acid and 8.4 g of anhydrous acetic acid were placed in a two-necked flask, and mixed. 5 Drops of sulfuric acid were added to the mixture under cooling with water. After heat generation ended, the mixture was heated at 80° C. for 30 minutes. Thereafter, the reaction mixture was poured into cold water, and a precipitated crystal was recovered by filtration. The crystal was dried in vacuum, and used in the next step.

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