Реакция #45429

Уравнение реакции

solution

(4-amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol

→

desired product

Выход 89.0%

4-amino-3-bromothieno[3,2-c]pyridine-7-carbaldehyde

Выход 89.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered through diatomaceous earth (Celite®)
2. 2
   ПромывкаThe pad was washed with THF and dichloromethane
3. 3
   Концентрированиеthe combined filtrates were concentrated

Методика

A solution of Example 277E (1 g, 3.86 mmol) in THF (100 mL) was treated with MnO2 (2.66 g, 42.1 mmol), stirred overnight at room temperature, and filtered through diatomaceous earth (Celite®). The pad was washed with THF and dichloromethane and the combined filtrates were concentrated to provide 0.88 g (89% yield) of the desired product. MS (ESI(+)) m/e 256.8, 258.8 (M+H)+.

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