Реакция #45397

Уравнение реакции

water

solution

3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine

NIS

→

desired product

Выход 70.0%

7-iodo-3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine

Выход 70.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered
2. 2
   ДругоеThe filter cake was purified by flash column chromatography on silica gel with 15% ethyl acetate/hexanes

Методика

A solution of Example 10A (1.69 g, 5.3 mmol) in DMF (20 mL) was treated with NIS (1.26 g, 5.6 mmol), stirred at room temperature for 3 hours, poured into water, and filtered. The filter cake was purified by flash column chromatography on silica gel with 15% ethyl acetate/hexanes to provide 1.64 g (70% yield) of the desired product. MS (ESI(+)) m/e 444.8 (M+H)+.

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